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Author Topic: Promising New Coronavirus Vaccine  (Read 136907 times)

Robert Roaldi

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Re: Promising New Coronavirus Vaccine
« Reply #2540 on: December 19, 2021, 10:12:20 am »

The bottom line is that scientists dealt a crooked hand with J&J.  ...

Change the record.
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Chris Kern

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Re: Promising New Coronavirus Vaccine
« Reply #2541 on: December 19, 2021, 02:21:16 pm »

Alan: STOP!

Fat chance of that happening—unless, perhaps, he can think up some other way to use his time.  Maybe a hobby?  He could take up photography, for example.

digitaldog

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Re: Promising New Coronavirus Vaccine
« Reply #2542 on: December 19, 2021, 02:36:13 pm »

Fat chance of that happening—unless, perhaps, he can think up some other way to use his time.  Maybe a hobby?  He could take up photography, for example.
I've complained to the site owners. I suggest others do the same. Now the burden is on them too. It is simply irresponsible for a forum or similar platform to allow dangerous lies and misinformation about vaccines, and Covid-19 during a deadly pandemic to continue. This isn't Facebook (of which I have never been and never will be a member), but social media or forums like this have to conduct some oversight into blatant lies and deadly misinformation during this pandemic.
He needs a hobby indeed. Photography was a fail. This is a photography web site and forum. If shutting this fool up means shutting down all discussions that don't have to do with photography, so be it. There are other avenues where Alan (and others) can regurgitate lies that have nothing to do with photography. The site owners here should consider that as well.   
« Last Edit: December 19, 2021, 02:48:17 pm by digitaldog »
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Eric Myrvaagnes

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Re: Promising New Coronavirus Vaccine
« Reply #2543 on: December 19, 2021, 05:03:26 pm »

Amen to that, Andrew.
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LesPalenik

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Re: Promising New Coronavirus Vaccine
« Reply #2544 on: December 19, 2021, 06:10:02 pm »

The bottom line is once again, Alan doesn't have a bloody clue what he writes* and jerks his knee here as exercise, deliberate deficient oversight and factual deficient ignorance:

https://www.bbc.com/news/world-us-canada-59692776
Alan: STOP! the deliberate lies and malpractice.

* "I'm all in favor of keeping dangerous weapons out of the hands of fools. Let's start with typewriters." -Frank Lloyd Wright
In this case a keyboard.
I wish the web site owners felt the same about these dangers and stopped this misinformation campaign.

We get many deliberate lies and misinformation also from Biden. I wish he stopped that.
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TechTalk

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Re: Promising New Coronavirus Vaccine
« Reply #2545 on: December 19, 2021, 06:17:37 pm »

I don't want to keep going down this road of correcting dangerous misinformation and advise endlessly, but it is important to call it out when you see it. I'd rather discuss the advances in medicine and public health and the hard work that research scientists and medical professionals do every day in an effort to save lives and protect our health.

I would like to shed light, however, on one other accusation made regarding the J&J vaccine with regard to its durability. I came across a recent article in the New England Journal of Medicine on that topic and an easier to read summary in the Boston Globe.

https://www.bostonglobe.com/2021/10/15/business/study-says-johnson-johnson-vaccine-immune-response-is-more-durable-than-pfizer-moderna

Study says Johnson & Johnson vaccine immune response is lower but more durable than Pfizer and Moderna

By Anissa Gardizy Globe Staff, Updated October 15, 2021

As the US Food and Drug Administration’s advisory panel discussed Friday whether to recommend a Johnson & Johnson booster dose, new research suggested the one-shot vaccine produces a lower but more durable immune response than the Pfizer-BioNTech and Moderna shots, which have been found to wane over time.

The findings, published Friday in the New England Journal of Medicine, come from a study of a few dozen people at Beth Israel Deaconess Medical Center in Boston, which analyzed blood samples of fully vaccinated people two to four weeks after vaccination, and then eight months later.

As was also suggested by previous studies, antibody responses from the two-shot Pfizer and Moderna messenger RNA vaccines peaked after full vaccination, and then began to decline six months later. The researchers found the decline continued after eight months. But while Johnson & Johnson’s one-shot vaccine produced a much lower initial antibody response, it remained “relatively stable” for the eight months observed, with “minimal-to-no evidence of decline,” according to the study.

Dr. Dan Barouch, who runs the virology center at Beth Israel and led the study, presented the data to the FDA’s scientific advisory committee on Friday morning, hours before the panel voted to recommend J&J’s booster for all adults at least two months after their primary dose of the vaccine.

“I think the data should be reassuring for people who received the J&J vaccine, that immune responses are stable over time,” he said. “After about eight months, the antibody responses are relatively similar among the three vaccines.”...

...Johnson & Johnson released data in September from a large clinical trial that showed a booster given two months after the first shot led to 94 percent protection against COVID-19 in the US.
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digitaldog

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Re: Promising New Coronavirus Vaccine
« Reply #2546 on: December 19, 2021, 06:35:03 pm »

We get many deliberate lies and misinformation also from Biden. I wish he stopped that.
You can petition the White House, I'm petitioning LuLa owners.
FWIW, I'm not aware of any lies from Biden that unlike some before him in the White House, lead to thousands or more deaths from Covid-19 lies.
Les, do you believe any of the following is a lie?

I was following the science.

The bottom line is that scientists dealt a crooked hand with J&J.  They deceived the public about its effectiveness.   Their oversight was deficient. They allowed a bad product to be fostered on an ignorant  public killing a lot of people.

So now that Covid is on the way out, we're left with the economic damage.
« Last Edit: December 19, 2021, 06:45:56 pm by digitaldog »
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TechTalk

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Re: Promising New Coronavirus Vaccine
« Reply #2547 on: December 19, 2021, 07:00:59 pm »

In much more positive news, the Novavax COVID-19 vaccine, which is the "Promising New Coronavirus Vaccine" news which began this thread, has made a great deal of progress. A couple of days ago the World Health Organization issued an emergency use listing (EUL) for the Novavax COVID-19 vaccine.

https://www.who.int/17-12-2021-who-lists-9th-covid-19-vaccine-for-emergency-use-with-aim-to-increase-access-to-vaccination-in-lower-income-countries

Excerpts below:

Today, the World Health Organization issued an emergency use listing (EUL) for NVX-CoV2373, expanding the basket of WHO-validated vaccines against the SARS-CoV-2 virus. The vaccine, named CovovaxTM, is produced by the Serum Institute of India under licence from Novavax and is part of the COVAX facility portfolio, giving a much-needed boost to ongoing efforts to vaccinate more people in lower-income countries.

“Even with new variants emerging, vaccines remain one of the most effective tools to protect people against serious illness and death from SARS-COV-2,” said Dr Mariângela Simão, WHO Assistant-Director General for Access to Medicines and Health Products. ‘This listing aims to increase access particularly in lower-income countries, 41 of which have still not been able to vaccinate 10% of their populations, while 98 countries have not reached 40%.”

Covovax is a subunit of the vaccine developed by Novavax and the Coalition for Epidemic Preparedness Innovations (CEPI). It requires two doses and is stable at 2 to 8 °C refrigerated temperatures. The vaccine uses a novel platform and is produced by creating an engineered baculovirus containing a gene for a modified SARS-CoV-2 spike protein.

The originator product produced by Novavax, named Nuvaxovid, is currently under assessment by the European Medicines Agency (EMA). WHO will complete its own assessment of this vaccine once the EMA has issued its recommendation.
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TechTalk

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Re: Promising New Coronavirus Vaccine
« Reply #2548 on: December 19, 2021, 07:12:56 pm »

Here's an article from the Center for Infectious Disease Research and Policy at the University of Minnesota which was published online few days ago regarding phase 3 trial efficacy of the Novavax COVID-19 vaccine.

https://www.cidrap.umn.edu/news-perspective/2021/12/novavax-covid-vaccine-shows-90.4%-efficacy-against-infection

Excerpts below:

Novavax COVID vaccine shows 90.4% efficacy against infection

A phase 3 trial yesterday in the New England Journal of Medicine (NEJM) finds that the Novavax COVID-19 vaccine is 90.4% effective against infection and 100% effective against moderate to severe illness, bringing yet another vaccine one step closer to approval.

Novavax is a new adjuvanted, recombinant spike protein nanoparticle vaccine that has proven effective against COVID-19 infection in the United Kingdom and South Africa. This was the first such trial in North America.

The study, led by Novavax researchers in Gaithersburg, Maryland, involved 29,949 adults who received the Novavax vaccine at 113 sites in the United States and 6 in Mexico from Dec 27, 2020, to Feb 18, 2021, before the emergence of the highly transmissible Delta (B1617.2) and Omicron (B.1.1.529) variants. Participants were followed until Apr 19, 2021.

The study authors said that Novavax's ability to be stored for up to 6 months at normal refrigerator temperatures make it well-suited for international deployment.

"The efficacy of NVX-CoV2373 [Novavax] in preventing moderate-to-severe COVID-19 as well as any symptomatic COVID-19 in people at high risk for acquisition and complications of COVID-19 will make this vaccine a valuable tool in controlling the pandemic and its most serious health and economic consequences," they concluded.

In a related audio interview, NEJM Editor-in-Chief Eric Rubin, MD, PhD, said that, in the context of great global COVID-19 vaccine need, it's good to have another effective vaccine candidate like Novavax. "For now, I think which vaccine is superior is less important than which vaccines work and are available," he said.

"I think we really need to get those vaccines out there, even if there are subtle differences among them in how effective they are or what side effects they have."
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Alan Klein

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Re: Promising New Coronavirus Vaccine
« Reply #2549 on: December 19, 2021, 07:22:12 pm »

I've complained to the site owners. I suggest others do the same. Now the burden is on them too. It is simply irresponsible for a forum or similar platform to allow dangerous lies and misinformation about vaccines, and Covid-19 during a deadly pandemic to continue. This isn't Facebook (of which I have never been and never will be a member), but social media or forums like this have to conduct some oversight into blatant lies and deadly misinformation during this pandemic.
He needs a hobby indeed. Photography was a fail. This is a photography web site and forum. If shutting this fool up means shutting down all discussions that don't have to do with photography, so be it. There are other avenues where Alan (and others) can regurgitate lies that have nothing to do with photography. The site owners here should consider that as well.   
Opinions are not a reason to be banned from this site. But personal attacks like you make are and I've complained to the owners about your continuing personal attacks and insults.

digitaldog

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Re: Promising New Coronavirus Vaccine
« Reply #2550 on: December 19, 2021, 07:27:35 pm »

Opinions are not a reason to be banned from this site. But personal attacks like you make are and I've complained to the owners about your continuing personal attacks and insults.
I'm no longer on your ignore list, another lie?

Quote
More of your personal attacks and condescending insults.  Posts pulled from other threads that have nothing to do with Covid and this thread.  Back on my ignore list.

BTW, I never said anything to anyone about banning your dangerous lies about Covid-19. Another of your knee jerk assumptions.

Quote
If shutting this fool up means shutting down all discussions that don't have to do with photography, so be it.
« Last Edit: December 19, 2021, 07:36:06 pm by digitaldog »
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Alan Klein

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Re: Promising New Coronavirus Vaccine
« Reply #2551 on: December 19, 2021, 07:49:15 pm »

I don't want to keep going down this road of correcting dangerous misinformation and advise endlessly, but it is important to call it out when you see it. I'd rather discuss the advances in medicine and public health and the hard work that research scientists and medical professionals do every day in an effort to save lives and protect our health.

I would like to shed light, however, on one other accusation made regarding the J&J vaccine with regard to its durability. I came across a recent article in the New England Journal of Medicine on that topic and an easier to read summary in the Boston Globe.

https://www.bostonglobe.com/2021/10/15/business/study-says-johnson-johnson-vaccine-immune-response-is-more-durable-than-pfizer-moderna

Study says Johnson & Johnson vaccine immune response is lower but more durable than Pfizer and Moderna

By Anissa Gardizy Globe Staff, Updated October 15, 2021

As the US Food and Drug Administration’s advisory panel discussed Friday whether to recommend a Johnson & Johnson booster dose, new research suggested the one-shot vaccine produces a lower but more durable immune response than the Pfizer-BioNTech and Moderna shots, which have been found to wane over time.

The findings, published Friday in the New England Journal of Medicine, come from a study of a few dozen people at Beth Israel Deaconess Medical Center in Boston, which analyzed blood samples of fully vaccinated people two to four weeks after vaccination, and then eight months later.

As was also suggested by previous studies, antibody responses from the two-shot Pfizer and Moderna messenger RNA vaccines peaked after full vaccination, and then began to decline six months later. The researchers found the decline continued after eight months. But while Johnson & Johnson’s one-shot vaccine produced a much lower initial antibody response, it remained “relatively stable” for the eight months observed, with “minimal-to-no evidence of decline,” according to the study.

Dr. Dan Barouch, who runs the virology center at Beth Israel and led the study, presented the data to the FDA’s scientific advisory committee on Friday morning, hours before the panel voted to recommend J&J’s booster for all adults at least two months after their primary dose of the vaccine.

“I think the data should be reassuring for people who received the J&J vaccine, that immune responses are stable over time,” he said. “After about eight months, the antibody responses are relatively similar among the three vaccines.”...

...Johnson & Johnson released data in September from a large clinical trial that showed a booster given two months after the first shot led to 94 percent protection against COVID-19 in the US.
A study of a few dozen people from a single Boston Hospital doesn't sound like a conclusive finding.  In addition, I don't understand why anyone would continue to defend J&J when people are dying from it.  Three days ago, the ACIP recommended using Moderna and Pfizer over J&J.  While the CDC hasn't yet acted on their recommendation, it's a pretty serious situation.

US panel recommends J&J shots be sidelined after clot deaths
A panel of US experts has voted unanimously to recommend the Pfizer and Moderna Covid-19 vaccines over Johnson & Johnson's, which has been linked to deadly side effects.

According to the US Centers for Disease Control and Prevention (CDC), a total of 57 J&J patients have developed a rare blood clot disorder.

Nine people are known so far to have died: seven women and two men.

https://www.bbc.com/news/world-us-canada-59692776

TechTalk

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Re: Promising New Coronavirus Vaccine
« Reply #2552 on: December 19, 2021, 07:51:42 pm »

You may continue to spin around in circles. I'm moving on thanks.
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TechTalk

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Re: Promising New Coronavirus Vaccine
« Reply #2553 on: December 19, 2021, 07:59:49 pm »

The Novavax COVID-19 vaccine utilizes a different technology than the current mRNA vaccines from Pfizer-BioNTech and Moderna or the viral vector J&J vaccine. It is a protein-based vaccine which has some advantages, as do each of the other vaccine technologies. Here's an article from nature describing how it works and some advantages. You can click the link below for a graphic illustrating how protein-based vaccines work.

https://www.nature.com/articles/How protein-based COVID vaccines could change the pandemic

How protein-based COVID vaccines could change the pandemic

Excerpts below:

So far, fewer than 6% of people in low-income countries have been vaccinated against COVID-19. Protein-based vaccines — with their inexpensive production protocols and logistical advantages, including stability at a broad range of temperatures — could help to narrow the immunization gap between rich and poor countries.

“The world needs these protein-based vaccines to reach those vulnerable populations,” says Nick Jackson, head of programmes and innovative technologies at the Coalition for Epidemic Preparedness Innovations, which has invested more than US$1 billion in five protein-based COVID-19 vaccines in active development. The lion’s share is going to products made by Clover, Novavax and SK bioscience in Seongnam, South Korea. “Protein vaccines are going to beckon in a new era of COVID-19 immunization,” Jackson says.

From the earliest days of the pandemic response, researchers anticipated that protein-based designs would be slower off the blocks than other vaccine technologies.

Companies know how to manufacture gobs of purified protein at scale — using genetically engineered cells from mammals, insects or microbes — but the process involves many steps, each of which has to be optimized for making a specific protein. “There’s an intrinsic slowness,” says Christian Mandl, a former industry executive who now consults on vaccine-development issues. Most of the protein-based vaccines currently in testing have been crafted around some version of the coronavirus SARS-CoV-2’s spike protein, which helps the virus to enter cells (see ‘Protein vaccines 101’).

Once authorized, protein shots are also expected to rapidly address supply shortages that have plagued efforts to vaccinate lower-income countries. Novavax and Clover, for example, have each pledged to donate hundreds of millions of doses of their jabs next year to COVAX, an initiative designed to distribute vaccines around the world.

The global health community has also been arguing that equitable access to COVID-19 vaccines could be achieved through local manufacturing of shots in the global south. To achieve this, more researchers should be looking to simple, inexpensive production systems that manufacturers in less-wealthy countries can readily implement, says Christopher Love, a chemical engineer at the Massachusetts Institute of Technology in Cambridge.

In the earliest days of the COVID-19 crisis, vaccine platforms such as mRNA brought the advantage of speed, says Ralf Clemens, a vaccine-industry veteran and a scientific adviser to Clover. But now that a wave of protein-based vaccines is coming, he says, they will have a lot more to offer — and in the long run when it comes to protecting the world against coronavirus infections, “I think they will prevail.”
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LesPalenik

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Re: Promising New Coronavirus Vaccine
« Reply #2554 on: December 19, 2021, 09:41:55 pm »

You can petition the White House, I'm petitioning LuLa owners.
FWIW, I'm not aware of any lies from Biden that unlike some before him in the White House, lead to thousands or more deaths from Covid-19 lies.
Les, do you believe any of the following is a lie?

Lies, inaccuracies or poorly chosen words, both are equally guilty of them.
The difference is that Alan's posts are read and scrutinized by a few dozens of sharp and skeptical old farts on LuLa, but Biden's speeches are transmitted on National TV and through global youtube clips to millions of naive and gullible MSM consumers. On top of it, I have corrected Alan quite a few times myself, but lack an effective way to confront the WH politicians. Ignore button is also a good way to filter out unwanted content (regrettably only on Lula).
« Last Edit: December 19, 2021, 09:53:30 pm by LesPalenik »
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digitaldog

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Re: Promising New Coronavirus Vaccine
« Reply #2555 on: December 20, 2021, 06:19:31 am »

Lies, inaccuracies or poorly chosen words, both are equally guilty of them.
You at least answered my question about Alan and this discussion of Covid-19, thank you.

Both Alan and Joe can have strong opinions about topics they know nothing about or even lie about such things in a forum or elswhere. Alan and Joe can tell us "When I was a teenager, I saw the premiere of Citizen Kane at the theater and it was shown in Technicolor". What neither Alan or Joe can yell is "Fire" in that crowed theater when the sled burns!

This site has some responsibilities durning a deadly pandemic that in the US alone has killed at least Eight Hundred Thousand humans to tell users not to lie and yell "Fire".
Alan's guilty conscience jerks his knee in suggesting that "Opinions are not a reason to be banned from this site" when banning isn't necessary for all the stupid and wrong posts he makes. Yelling Fire, does call for intervention. 
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Alan Klein

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Re: Promising New Coronavirus Vaccine
« Reply #2556 on: December 20, 2021, 08:55:34 am »

Lies, inaccuracies or poorly chosen words, both are equally guilty of them.
The difference is that Alan's posts are read and scrutinized by a few dozens of sharp and skeptical old farts on LuLa, but Biden's speeches are transmitted on National TV and through global youtube clips to millions of naive and gullible MSM consumers. On top of it, I have corrected Alan quite a few times myself, but lack an effective way to confront the WH politicians. Ignore button is also a good way to filter out unwanted content (regrettably only on Lula).
I'm sorry Les.  You're incorrect.  I haven't lied. And I'm disappointed in your accusation and agreement with Andrew a man whose every other post smears someone, not only me.   Like everyone else here, I present evidence to support my point of view.  And others present their evidence to support theirs.  Just like opposing sides in court.   Truth lies in the eye of the beholder.  It;'s up to others to draw conclusion of what they heard and make up their own minds.   

Of course, everyone makes errors on facts.  There's no way anyone has a monopoly on them.  We can't know everything.  Plus facts change from day to day.  What was understood to be true yesterday may be untrue today and vice versa.   

I was accused of lying about how J&J vaccine killed people.  That's the truth and you can see my article above.  So Andrew lied.  Yet you don't seem concerned about his lies, distortion,s and personal attacks.  You don't seem to acknowledge your poorly chosen and inaccurate comments but only see them in others.  It's very disappointing to hear this from you. 

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Re: Promising New Coronavirus Vaccine
« Reply #2557 on: December 20, 2021, 09:01:40 am »

The bottom line is once again, Alan doesn't have a bloody clue what he writes* and jerks his knee here as exercise, deliberate deficient oversight and factual deficient ignorance:

https://www.bbc.com/news/world-us-canada-59692776
Alan: STOP! the deliberate lies and malpractice.

* "I'm all in favor of keeping dangerous weapons out of the hands of fools. Let's start with typewriters." -Frank Lloyd Wright
In this case a keyboard.
I wish the web site owners felt the same about these dangers and stopped this misinformation campaign.


I presented evidence that shows J&J vaccine killed 9 people and made dozens more very sick with blood clots.   Telling me to "STOP IT" is not evidence that my facts are in error or a lie.  Stop lying to people here on LuLa on the dangers of J&J vaccine. You're spreading misinformation that's dangerous to the people here. You should not cover up for J&J.

digitaldog

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Re: Promising New Coronavirus Vaccine
« Reply #2558 on: December 20, 2021, 09:36:33 am »

I presented evidence that shows J&J vaccine killed 9 people and made dozens more very sick with blood clots.   Telling me to "STOP IT" is not evidence that my facts are in error or a lie.  Stop lying to people here on LuLa on the dangers of J&J vaccine. You're spreading misinformation that's dangerous to the people here. You should not cover up for J&J.
You've lost it man, get a grip and at least look at what you wrote and exactly when! Indeed Alan, you should:Stop lying to people here on LuLa on the dangers of J&J vaccine. You're spreading misinformation that's dangerous to the people here. "STOP IT".
I don’t know if you are purposely trying not to understand this, or if you simply cannot understand it.   


« Last Edit: December 20, 2021, 10:03:23 am by digitaldog »
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PeterAit

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Re: Promising New Coronavirus Vaccine
« Reply #2559 on: December 20, 2021, 11:37:59 am »

I'm sorry Les.  You're incorrect.  I haven't lied.

I have to support Alan here. To "lie" is to intentionally say something that you know is false. I don't think Alan does that. Of course, many of the things he says are factually false, but he believes them--so, no lies. I also do not recall him ever making a personal attack.
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