I've never had to do a "clean" on W10 printer driver unlike Mac, reinstall has always worked. I would not jump to reinstalling PS. The Epson website has W10 drivers dated 10/18 (I couldn't tell from your post as to your driver source), I recommend keeping them current, given the W10 frequent updates. Also check firmware version.
Don't want to be insulting, but make sure you're printing "portrait" orientation even if you have to flip landscape image in PS, i.e. don't make the printer driver rotate your image.
Richard Southworth
Added by edit - grasping at straws, try another USB cable?