I've got the Mission. It's pretty bare bones, but works very well. The suspension system is very comfortable (for me anyway). Much more so than any of the LowePro packs I've hauled around. My only gripe is that it could use a few more exterior pockets. Plenty of interior room for day-gear and I've used mine for BC skiing as well (tight with a shovel, probe, and day gear + photo gear, but manageable). The removable cube is nice for throwing in my larger Mountain Hardware pack when I'm going on overnighters. Overall it's a great pack for the price.
Don't know much about the Reload though.