Canon is passing the buck. Its their bug if they can't behave like Epson with these grayed out radio buttons.
Some software products use a private (undocumented) SPI called kPMApplicationColorMatching, which you see in Photoshop, Lightroom, Adobe Color Print Utility, the ColorSync Utility, etc. When you set Application Manages Color, the area of the driver that controls Colorsync will alter the radio buttons so they are grayed out. X-Rite’s i1Profiler and a few other software products have also implemented this SPI.They work as well.