The Z7 is specifically compared to the D850 in durability and weatherproofing - Nikon emphasizes that, and the bodies I handled definitely felt that way - they were really solid.
Due to the inherent advantages of on-sensor hybrid phase/contrast AF, I suspect the focus precision of the z7 will eclipse any other Nikon (the RF should eclipse any other Canon as well). AF coverage on most newer mirrorless designs will be wider than any DSLR, from any manufacturer - this is just an advantage of on-sensor AF over any viable separate sensor (and, even if you're willing to use a DSLR in live view without an eye-level viewfinder, nobody has put a huge number of PDAF points on a DSLR sensor yet). AF speed won't be as fast as the best DSLRs, although it's better than an X-T1 by a significant margin.
The Z7 has a relatively slow framerate (the Z6 and the Canon RF are both faster), but you aren't taking the film holder out and turning it around after every shot, and it's getting close to 4x5" film resolution (it's probably better than almost any sub-4x5 film, and 6x9 cm, another possible comparison, was never a film format known for high frame rates, either). How often do you need both absurdly high resolution and the framerate of a movie camera?
The idea of the Z7 is to take a very, very, very high-quality sensor and put it in a durable, ergonomic package with superb optics. It's not meant to be the ultimate Instagram camera, the best choice for shooting the Olympics or the Indy 500, nor even necessarily the best camera for day-to-day shooting if you don't print big (it'll happily melt your computer and overload your drives, and it doesn't offer the ideal lens for pictures of the kids).
It's built to be Galen Rowell's dream camera - the most image quality you can haul the farthest from the trailhead and bang around/get rained on. It also has applications in some places where medium format digital is the other choice - fashion, architecture and product photography (and the focusing is far better than current MF digital). The D850 works just as well in those applications, but no better. From the early "reviews", the Z7 will probably succeed at its goal...
The Z6, EOS-R and A7III are meant to be more versatile - they offer good resolution, although not as jaw-dropping as the Z7, more speed and they're cheaper with files that are less of a pain to edit.
If you can lift your printer by yourself (unless you're a bodybuilder and can somehow lift a modern 24" or 44" printer!), you are not the Z7's target customer (or the A7r III's, for that matter). It feeds big, luscious files to big, ugly printers for big, gorgeous prints, and that's all it does.