Complete wild guesses.
Are you trying to print a PSD file?
Are you trying to print a TIF file that is not flattened?
If you have flattened it did you remove any Alpha channels, paths, everything other than RGB, r, g, B, in the Channels panel?
Are you using a Mac? If so what do you see when you Ctl-click and Open with Preview app? What happens when you print then?