I turned off graphics processor, restarted PS, no change in image. Tried opening as a smart object, again, no change. Saved as a jpeg out of ACR, then opened in CC2015, same problem. The 2 images, in either Prophoto or sRGB appear identical to each other. Neither looks like the preview in ACR. In PS, the images are greatly over-saturated and the image appears much darker. I do not have proof colors turned on, so I am not simulating anything. If I move the image in Bridge from the Cintiq to my monitor, there is only a small change to the image, it appears a bit lighter. Since I use the monitor only for pallets, it is not calibrated. The Cintiq provides a very accurate display. I do all my retouching and previewing on the Cintiq and if I print, the print matches the Cintiq, both for color and density. I have PS CS5 and CS3 both loaded. Both programs are set to the same color settings, i.e. ProPhoto. If I open jpegs in CS3, I get a message that the profiles don't match the working space. If I choose to convert or if I use the sRGB profile, the images appear the same and they match the preview in ACR. If I open the PSD which has a Prophoto profile in CS3, it appears overly saturated and dark, just like in CC2015 and in CS5. I have 3 attachments, one showing the color settings in CC2015 and the other 2 showing the color settings in Bridge. Something that is new and may be the source of the problem is the synchronization of color settings. I am just lost here. Something is wrong but I don't know what it is. This is not a problem of long standing. This is a new computer, but same monitor and Cintiq.