I do find the need to reboot occasionally to clear out the cobwebs with i1Profiler. (Actually, I think it's more likely an issue with the lower level software like XRD Services.) Sometimes during a profiling run the software will lose communication with the table/spectro and either hang forever, or abort with an error. When this happens, probably half the time simply exiting and restarting i1Profiler doesn't work. So now whenever I hit an issue, I just reboot first, and then try again.