I agree with huguito. Both sides print very nicely, take ink enormously well, but the front and back surfaces are different. I've used Epson Hot Press and Cold Press in the past for fine art greeting cards, employing two-sided printing. I used the correct side for the card exterior, which contained photographic art in my case, and the inside for text and shapes. But both sides took the ink similarly well. Cold Press differs from Hot Press in the surface textures, as you probably know. Each is available in Natural and Bright which, as you'd guess, relates to use of brightening agents.
If your printing application were a book, or some situation in which you wanted each doubled-sided printed surface to look truly identical, I'd probably not use this paper.
While I generally dislike Epson papers and almost never use them on our 9900 and 4900 machines, I do consider the Cold Press and Hot Press papers about as good as any MK paper I know of.
John Caldwell