I almost always shoot my panoramas on auto and Photoshop never had problems in evening it out.
I agree with Slobodan that many differences can and will be automatically evened out in a good blending engine. It does however depend a bit on the lenses used,and the amount of overlap. So I'd just give it a try, and only if needed do a manual correction before the actual blending.
A possible approach is to use two layers in Photoshop, draw a selection in the overlap region, and try to match the median value of one layer (e.g. the lower one) with the other layer, by using an Exposure adjustment layer in between the two. The match will be closest if the images are already aligned/warped, but even doing it on the originals before alignment should get you close enough for the blending engine to do the rest (vignetting, lightfall-off, etc.).
Cheers,
Bart