Used as a high-magnification telescope, my Mamiya 200/2.8 APO peaks at f4. The resolution of detail, on the Moon or Jupiter for example, is equally good at f2.8, but the contrast (hence the MTF) is a bit lower.
At f4 it shows a really nice clean Airy disk.
At f5.6, the Airy disk is visibly larger, due to diffraction, and of course dimmer. And so on, down to f22. It's really fun to watch the Airy diffraction versus f-stop progression.You can't do that on a regular telescope - there's no aperture iris.
So what I usually do is use f4 for viewing the bright stuff where light is a given and contrast is needed instead (Moon, planets, double stars etc.), and f2.8 where maximum light grasp is best for sweeping the faint deep sky stuff, RFT style.
If I had the 300/2.8, that would be even better. 50% higher angular resolution at the same f-stop, and 125% more light grasp.
I know some of you guys have the 300/2.8, but you waste it by only taking photos through it

Ray