I did try Synback and Syntoy, but I had some issues with one of them, I'm not sure who did it but I lost a couple of months of pictures; I had backups on about 5 different harddrives but somewhere the Synback/ Synctoy missed those months and when my regular harddrive died every backup was missing the same picures.
Now I use Alwaysync (the paid version on USB as I went over the 40,000 free limit easily) to have the same pictures and documents on multiple drives. You can use to USB version and move it from computer to computer with different backup jobs. So far so good (but then again, that's how it was with the previous sync programs until I had a problem).
For backup I use the Windows Home Server, and it actually works. It backs up my 2 laptops and the desktop (Win Xp prof, Wind Vista Home, Win 7 64 prof), automatically. The transfer rates are ok, though not great. Not much better than a previous FreeNAS server on the same hardware. However the folder duplication is really nice, better than software RAID as you don't need to rebuild the RAID to get the data, plus you use the space more efficiently. And if you don't need high speeds at all times is better than hardware RAID, because if your RAID controller dies in few years and you don't have RAID1, you need the same controller. (this is for storage, not workstation - I use RAID0 for that)
It actually works, I had to use it to completely restore a Vista laptop as the initial Win 7 uppgrade didn't work. The only thing you have to remember is that WHS is 32bit, so if you want to restore a 64bit system you need the LAN driver in 32bit in order to work.