They are definitely different. In general the Saturation control on the Vibrance panel is a little slower/more subtle. The manual also states that the Saturation control on the Vibrance panel may help with banding compared to Hue/Saturation (which makes sense I guess if it is more subtle).Here is a link where this gentleman analyzed the difference in quite a bit of detail:http://www.photo-mark.com/notes/2009/jan/1...and-saturation/