Bill, I use XP, not Vista, but FWIW a suggestion of what is PERHAPS the problem: even though it should be, the new profile may not be set as the new default in the video card driver. If Vista works similarly as XP in this respect, right click your desktop, select Properties>Settings>Advanced>Color Management, highlight the newly-made profile you want as the default, then click "Set As Default", OK close., and the selected profile should return automatically regardless of what the screen saver does.