The DNG editor is very easy to use, IMHO.
I photographed a MacBeth color chart outside on a clear day and then inside with tungsten lights. I did this for various ISO settings from 100 to 1600 and created custom profiles for my Canon 1DsMKIII and 40D.
The results are very much improved over the standard LR2 defaults. It's still a process of trial and error, but the results are worth it.
Bud James
North Wales, PA