I feel like there are about three different discussions going on at once here, with each person attacking the problem based on what he thinks is the issue.
All I can add, from one user's perspective, is that I saw a centerfold effect, whether or not it's the classic centerfold that plagued Leaf or not, in my P21 (non-plus), using Lightroom 1.0, at ASA 400 setting. It scared me enough to not use Lightroom again, since the problem did not occur using CaptureOne on the exact same file.
I feel like the original question was not stated clearly enough to solve it -- whether his issue showed up in CaptureOne or in Lightroom.
Again, my advice during this shakeout period, where it's unclear how much solid information that Adobe has from Phase about the makeup of the RAW file, is to use CaptureOne for now. If Lightroom works for you, you are a lucky man; you are living right. But my own personal view is that Phase is not talking to Adobe at all, due to competing software, and whatever Adobe gets out of the Phase file is pure accident, and is due to Adobe's skills. Personally, I will rely on CaptureOne for now, feeling as though I'm getting 100% of the file's information.
This is one photographer's subjective opinion only.