I have used the Domke F-2 for 14 years now and it's still my favorite. It's amazing how much stuff you can get into it.
And as Sheldon says; "..it doesn't feel overly large even when I just have a single body and an extra lens."
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Get the Lil' Bigger Bag... The F1x I believe. You can never have enough bag.
Domke is a great choice. My Domke "Original" bag is going on twenty years old and is still in great shape.
Oh... my F1x holds two DSLR bodies (one with lens attached), a Canon 70-200mm f2.8, 100mm f2.8 Macro, Tokina 12-24mm, Canon Speedlight, Flash bracket, bubble blower, Audobon Society field guide for birds, close up filters, CF cards, extra batteries, etc.
The "Original" Bag will handle one DSLR (lens not attached), three lenses and the flash, plus a ton of small gadgets.