Except some commercial solvent or UV printers, Epson driver runs under RGB data. The driver will take over the rest of works. You can only sent CMYK, actually C-lc-M-lm-Y-K-lk-llk-O-G..., directly to the printer via RIPs.
Proofing is not the only reason to do that, detailed and fully control of each inks is. An example, I could push the gamut to 94% Pantone coverage on Epson 9880 by fine turning every ink limit, while Epson claimed 85%. Moreover, using proper GCR settings and black ink amount, density could be increased by over 0.2 on the same paper.