Yes, put the 2 images as layers in Photoshop, set the top one to Difference mode. You will see a black image, which tells you nothing. So, display the histogram. Click on the little yellow triangle warning in the histogram window. That warning is telling you the histogram is an estimate. Once clicked, the histogram becomes real.
Read the StdDev value. If it is zero, the images are 100% identical. If not, they are different. If StdDev is below 1.0, the difference is insignificant. To see where the differences are, add a Threshold layer on top. Move the slider to the far left, then slowly nudge it to the right. White means difference, black means identical.