Large changes in delta E occurred printing with my Canon Pro 1000 in the last month. In the worst case the change was (dE1976:11 or dE2000: 5). I have never seen this amount of change on my Epson 9800.
Back at the start of Dec., I'd been printing on the same Pro1000 cartridges since about May and they were about 1/3 empty except for two that were near empty. GY and PBK. Around the 4th they issued the low ink warning but there's still quite a bit of ink left so I've been running them until they quit not thinking too much of it. As of now (Jan 3) they still haven't run out.
However, I've been developing a tool to evaluate profile patch sets for accuracy that's specifically designed to minimize printer/ink variations. Along with that are mechanisms to track changes over time. Both to evaluate ink color stability on a print and such things as drying time impact. This involves printing a linear ramp, RGB(0,0,0),(2,2,2),(4,4,4)...(30,30,30) as well as a set of all colors using 0, 85, 170, 255 in each RGB channel. This is a total of 79 colors. These are then repeated to fill a full page and duplicates each color 12 to 13 times. Averaging these gives a pretty precise estimate at the time the page was printed then measured.
The unexpected happened. The colors shifted radically after the ink warning light came on but while the printer still continued to print. In the worst case the color associated with RGB(255,0,85) a slightly orange-ish red, shifted 9 deltaE's after 20 days to 11 deltaE's after 30 days. In the latter case the original Lab value was (50.05, 77.34, 42.14) and 30 days later it printed as (48.76, 77.08, 53.19). More saturated and darker. This might be consistent with ink in cartridges gradually drying and becoming denser. I would expect, from the principles of physics, this would occur at higher rates as the remaining ink got lower. But this seems rather much.
Needless to say, this sort of error greatly exceeds any inaccuracy caused by using a small patch count, say 400 v 2000 when making profiles.
The printer has passed nozzle checks in each case prior to printing.
