As long as there is no IBIS system on the sensor, it should be straightforward. If you have IBIS, the camera needs to be on, to lock the sensor down, as when off the sensor is free to be moved and from what I have read, not a good idea. I am not a fan of wet cleaning with the camera on, however with the GFX100 and Nikon Z7, I have gotten used to it. The Nikon rarely needs cleaning, but the GFX100 quite often, more than a simple blow off.
Paul