I have used ON1 With Lightroom for several years, primarily for its effects. I purchased the NoNoise software which was released today. I have tried it on three photos so far. I had some particularly noisy files from my D800 (long story) shot at 6400. The software cleaned up the noise very nicely without reducing detail.
I recommend viewing the short video tutorials ON1 provides for a fast start.
My work flow will be import into lightroom. Cull. Chose files needing noise elimination and run them through NoNoise without lightroom adjustments. Return adjusted files to lightroom as DNG files.
I have some files in my library that I will experiment on and see if the process holds up.