I suspect no one cares much about this topic anymore but after quite a bit of fussing about, it may be solved. I had a productive conversation with the folks at OWC/SoftRaid. We tried to determine if the problem was the drive or the enclosure. I have a Thunderbolt 2 connected Thunderbay 4, where the drive in question lived, and a Thunderbolt 3 Thunderbay 4 connected by an adapter cable, both to my 2013 Mac Pro (trashcan). With their guidance, I tried substituting another drive in the problem slot and all seemed well, I thought it was the particular drive, though it was an almost newToshiba 12TB bought from OWC in June. Long story short, once I put the drive into the Thunderbolt 3 Thunderbay, all was well. I've slept and awakened the computer a number of times and have not seen the dreaded message. I am hopeful I've seen the last of this problem.