The official Epson ones are (although even then it's just a matter of plastic pieces that can be cut off) but most 3rd party carts are all just the same to save on manufacturing costs. If you're using sawgrass or something like that then you may want to do yourself a favor and get a chip resetter-- sometimes I've had those chips be faulty and I've been able to use ones from older carts to replace them. IIRC from my testing on this years ago, the "plain paper" setting might be one of the only ones that doesn't attempt to put other colors in the black when printing with the Epson driver to achieve a "rich black" -- something like an Epson secret sauce-- I struggled a bunch with this before giving up on RGB profiling for dye-sub and getting set up with Ergosoft. The other benefit to that was being able to tell the RIP that any ink is in any slot I wanted, so when the Sawgrass ink eventually took a channel down, which it always did after a few months, I could switch around and use other unused channels or eliminate a light ink instead of replacing the head right away.
This was all on 9890/9900 series, so maybe the P8000 fares better with the (supposedly) improved coating on the heads in that generation--