That will be an impressive project.
Let's say 24 images (6 vertical exposures in 4 rows), times 3 HDR exposures, times 3 focal adjustments = 216 total images.
I have stitched over one hundred individual 24MP 360-degree HDR images (no focus stacking) with PTGui, so the process is feasible, but of course a fast computer with a lot of memory will help. I would do it in two passes, first pass without the focus stacking, and then combine the three (assuming focusing at foreground, middle ground, and infinity) layered panos into one.