Will the Epson R3880 with OEM Inks and Manufacturers Canned Profiles accept an image in ProPhoto or is it best to convert the space down to Adobe RGB.
Assuming your printing
software is properly colour managed, then yes. The conversion from ProPhoto to the output space is done in software, not in the printer.
Photoshop, Lightroom, QImage, PrintTool etc are all colour managed.
Tim