Just wanted to add a datapoint that my pro-4000 needs a head replacement after 2 years. It's a low volume printer with only 100k megadots. Got an EC21-2F51 error yesterday followed by dropping 1/3rd of the PK lines. A deep clean fixed it but later one of the colors (whatever makes the red not orange and the blue not purple) went out. A system clean got it working again but this morning I got another EC21-2F51 error and I called support who told me to buy a new head. I had recently noticed my d-max had gone down and a couple of colors were looking a bit off, so hopefully this fixes that issue. Printer has been powered on almost continuously for the 2 years and never had any clogs that weren't automatically detected and worked around.