The examples I have been able to view from both 6400 and 12800, averaged, make the images appear very close if not exactly the same as images from ISO 400, to 50. Averaged 50 images I don't see any if any gain in noise reduction. However the 6400 images have much better color fidelity and details, unlike a single 6400 shot.
So ISO may have nothing to do with it, but for the P1 solution it seems to make the camera ISOless, in effect everything looks the same. Except for the motion issues which unfortunately make the use of this tool outdoor very limited. Still makes sense to attempt a shot unless the conditions are just too harsh.
It's also interesting to see that P1 did not get the XF vibration sensor incorporated into the process, so that the XF is contributing to slight blur.
I noticed this with the official P1 landscape image, and a simple run of Topaz sharpen AI, using the stabilize setting seemingly pulls a lot of of that lost finer detail back. Made a big different on the P1 test file for sure.
Paul C