Once the colour temperature of the colour image is optimized then converted to B&W (as Mark recommends), I recommend NOT using the individual sliders in the B&W panel. Instead, click on the Targeted Adjustment Tool, hover over the tone you want to lighten/darken, click and drag. Most tones are a blend of individual colours. Dragging just one slider can result in a grainy-looking effect within the tone as some pixels within what you see as a single tone are altered more than others.
As Mark pointed out, dragging in one location will change the values of the same colours in the whole image, so, beware! Using a colour range mask in LR CC may allow to further refine specific tones, but I’m not a CC user, so cannot comment.
Using the B&W panel well, plus a few other adjustments - all within LR - has meant, for me, no trips to PS and no use for Silver Effex, despite the hype about both.