Yes the weight of the cameras is a major factor, besides IQ. For instance,
Nikon Z6 + 24-70, 1175g, 2.5lb
Canon RF + 24-105, 1360g, 3lb
Sony A7III + 28-70, 895g, 2lb
Fuji X-T3 + 18-55, 849g, 1.86lb
As I have a Fuji X-T2 and a Canon5D3, my lightweight camera is the X-T2 which I now use most of the time with the 55-200 lens as well as the 18-55, and I am very happy with the results. This means that the only candidate is the X-T3 which I bought today, trading in my X-T1. I cannot justify the cost of changing systems, particularly as I have some Fuji primes which I find excellent.
That's just my view.
Best wishes,
Jonathan