Doug: it's been a couple years since I was actively involved in scanning, so take the following with a generous helping of salt. Michael's 4000 ppi ceiling works for me ... assuming that the scanner's rated ppi is in the same ballpark as its actual ppi. The question in my mind is how much lower can you go? I suggest a test series along this line:
Find a really sharp slide with no DOF issues; scan it at 5000 and at whatever lower ppi options your scanner offers (real, not interpolated). No need to scan the whole slide if you can scan just a cropped area. If you didn't crop in the scanner, you can crop now to get a good part of the frame, maybe 2000x2000 pixels from the 5000 ppi scan. For the sake of the test, up-res each of the crops from the lower ppi scans to the same size as the crop from the 5000 ppi scan. Now give each as much USM as needed to regain the acutance you are used to seeing at actual pixels, then print. If any of the lower ppi crops shows no degradation compared to the 5000 ppi crop, then with some further testing you might be able to stick to that scan res for future work.
The main benefit of 16-bit is to minimize the damage from radical contrast and colour changes in post-processing. If you don't anticipate needing to do a radical edit on a given slide, you can forgo the extra bit depth; but of course this is also something you can put to the test.
Another perspective, however, is to make your best scan - 5000 ppi @ 16-bits/ch - of each slide you consider potentially worth printing, archive that as a master reference file, then do your post-processing on a down-sampled and bit-depth reduced copy should practicalities so dictate. The ideal here is that you would shed no tears if your dog chewed one of your slides so long as its master reference file remains safe.