Mark: The OP indicated he doesn't know yet what he wants to do with it. So for him, scanning it at max optical resolution the scanner can do is best. I'm glad you agree with that. As far as disk space, he'll get 35mb tiff for each slide. He could save if he saves in jpegs but it will only take 37gb to store 1000 35mm slides in tiff. That's nothing for most hard drives today with TB capacity. Anyway, he'll probably blow his brains out by the time he scans 1000 slides, so it won't matter. One question you can answer, what's the most real optical resolution can you get from a V750? I'm not familiar with that model. Do you have any figures on the V600? I use 2400.
ICE is good but it increases the time it takes to scan. You still have to go back and check and spot some anyway. That's something Pete can try both ways to see what works for him the best.
Regarding your recommending Silverfast, I think it's incumbent for the purposes of disclosure that you mention that you published and sell a book on using Silverfast and have an interest in it's success. I never used it and it could be the greatest. But I haven't been convinced to make the switch by what others have posted about it. Seems to be very difficult to set up the parameters to get the scan right. And then you have to scan again if it isn't right. That doesn't happen with Epsonscan if you scan flat without any edits during the scan process. Again, that's something that Pete can try both ways since he should have both programs with his scanner.
Alan, just a few factual points:
In his question, the OP did not say anything about purpose and he didn't say he doesn't know what he wants to do with the scans - that's why I asked, because unless you go for maximum CCD resolution, purposes matters to the answer he wanted.
Re the questions you asked me: the CCD resolution of the scanner according to the ISO standard with which it complies is 6400 PPI. This does not tell the story about either the resolving power of the scanning system, or the settings you should use. See my reply to Alan Fairley on all that, just above. I do not know what the ISO standard resolution of a V600 is because I don't have that scanner and never used it. The best way to decide what input resolution you should use for your purposes it to make tests, print the results and compare.
There is no secret I wrote a book about scanning with SilverFast 8. It was publicly announced on this website. I have no commercial interest in LaserSoft Imaging, they can sell as many or as few copies of their software as the market determines and it has zero impact on me. Trust me Alan, you can ask any author with the possible exception of Scott Kelby - you don't get rich writing such books - especially on a topic as arcane as this one with the limited residual market there is for the technology altogether. Selling a few books more or less passes under the radar - way under. I feel blessed and fortunate that I need not even think of depending on this stuff to put food on the table.
Not to put too fine a point on it - but I'm actually quite agnostic about software - for me, it's whatever works best in a systematic workflow for getting quality and efficiency. iSRD, as an example, happens to be a really good tool. It does not slow down scanning and from my experience with it, I'd say it eliminates just about all the crap you need to eliminate without impairing the image one iota. There can be "outliers" it doesn't pick up and those one deals with in LR or PS. Not to toot my horn inordinately, but a major emphasis of my book is about integrated workflows that combine SilverFast with Lightroom and/or Photoshop. Each of these applications have their strengths, weaknesses and optima, so after a great deal of research I've shown how many ways there are to skin this cat (and there could well be more, who knows). There are no pat answers - just different ways of doing things that have their pros and cons. This happens to be one particular area where dogma should take a back seat.
Finally, the nice thing about all this software is that the companies allow us to download and demo them. I encourage anyone who asks me to do just that - its free except for the time it takes to install, learn and play, see what floats your boat. Above all, I discourage being overly influenced by other peoples' problems on the internet. Remember Dragnet in the old days - 8 million souls, 8 million stories.........
Cheers