I have never done it but can't anticipate any more problems than with 17" rolls. Just have an additional 50mm or so at the end of each image so that that the image is clear before the end of the paper.
Well the difference would be that with a 17" roll, and cutting/printing on an eg. 17x25, the grain would be running the 25" length (ie. the same direction the paper feeds thru the printer). Cutting off a 17" sheet from a 24" wide roll, it feeds the opposite way. Ie.. the curl runs the opposite way. I thought this might yield problems.
50mm = almost 2 inches.. I've printed 16x24" images on 17x25 sheets without a problem (ie. 1/2" (or about 13mm) borders). Not sure I understand your recommendation?
Rethinking, but brings up its own headaches, is using 24" roll, from which I can get (from each 25" length), 1x a 17x25, plus 5x some 5x7 sheets. This is attractive in its own right, except for the cutting headaches..