Josh,
I should add a couple of points:
Yes - wherever you have the original negatives, it is best to scan those rather than the prints. Resolution and tonality will be much better. If the negatives are 35mm, while the Epson 750 will handle them decently, you would get superior sharpness from a high quality dedicated film scanner, which is hard to find these days. In the new scanner market, a Plustek 8200 is good; in the resale market you won't do better than a Nikon 5000, but it will cost you.
SilverFast has a batch scanning capability useful for frames generated in an Epson V750.
Re workflow, SilverFast has both a guided workflow pilot which takes you through the process in a logical sequence, but you can also use it in an unguided manual mode, where some additional features are available. Between the two you'll be OK.
There are image preparation functions (dimensioning, resolution, file format, bit depth, for colour materials white balancing) you should do in the scanner software and others (luminosity and colour) where editing functions are optional as between the scanner software and another application such as Lightroom or Photoshop. They have different relative advantages and more can be said about this than I can stuff in a forum post, but some experimentation will get you a long way to sorting out your preferences.