I had a similar problem once with my old Epson 1680 scanner. Turned out there was some schmutz on the semi-transparent strip of glass that lies next to the scanning area. On my scanner it's between the scanning glass and the cover hinge, and I believe it's called the Calibration Window. Once I cleaned off that strip, the problem disappeared.
In looking at the manual, I see that the window is used only for transparency scanning, to calibrate the brightness of the light source.
I could be talking through my hat, so take this suggestion for what it's worth.
MB