I think if you're selling in upper-tier galleries that cater to serious collectors, small limited editions seem to be the way to go. Small being somewhere in the neighborhood 5-20 prints, and not 'cheating' by offering a different editions of the same image in slightly different sizes or presentations. High-end collectors look to limited editions because in theory the scarcity of the prints should increase their value over time. So anything you do to increase the number of prints you can sell just defeats that purpose. If you're going to do limited editions, do it right and don't be disingenuous about what you're actually offering.
But again, I think this approach only makes sense at the higher end of the market. If you have the name recognition among collectors and can get 5-figure sale prices for your prints, that's great. For most of us, that's just not realistic; and I don't think limiting editions does the photographer any good if your prints are priced at several hundred dollars. It's not going to substantially raise the market value of your prints, but it does mean missing out on potential income if a popular image manages to sell out.
Limiting to 1000, 500, or even 100 prints strikes me as more than a little silly, unless you're famous and have your own chain of galleries (eg Mangelsen, Lik, etc). Not only are the chances of a relatively unknown photographer selling out such a large edition unlikely, but such large editions just aren't going to appeal to collectors who are buying with appreciation in mind.
For me personally, I know I'm not going to get into high-end galleries, and accept that serious collectors buying art as investment are not going to be interested in my work. That's fine by me, I'm more than happy selling prints to regular folks who just like the image and think it would look nice hanging on the wall in their home. So my prices reflect the market I expect to sell to. I do sign & number the prints, and include a certificate of authenticity, because I think that helps set them apart from a mass-produced poster or Costo mini-lab print. But I just don't see how limited editions would do me any good, nor does it matter to the market I'm selling to.