John - to say 4x5 is a different experience is obvious and true, used 4x5 for over a decade and MF for two decades. That said, it is a matter of taste and personal choice, I for one would not go back to film ever, and a mfdb or 4x5 digital back is way too much. For me, I like having a more portable system, more responsive system, a more multipurpose system, and a dslr is thing for me. As I said, YMMV. I think you will be good with your 5D2 and less stitching. Does not mean you can not stitch when you want to. I frankly could go either Canon or Nikon, have pretty comparable systems in both, but have personally had too many focusing issues with Canon, went through 3 5d bodies before I got one that focussed predictably, consistently. MF adjustment is just not my thing, I hope Nikons inclusion of this function is not a sign that future models will be more problematic. So far my d300 is fine with all my lenses I currently own. Personally I think 60-100MP is a bit overkill, but you may view you prints closer than I do. Although friends of mine think I am way to picky as is. I can tell you just from what i said before, that 30+mp is fine for 30x45 prints, the image I included above looks great at 30x60 inches. Looking at cropped sample images, at this size, I can only imagine what a image with twice the pixels would look like. Hope you 5D2 works for you, you will for sure, be able to stitch less and still acheive large file sizes, at this point I am waiting for a D700x model to arrive, to accomplish the same thing. IF you are surely, going for 60-100mp, you better make sure, your computer is up to top form in RAM and hard drive space....have fun, going to Greece in March and will surely shoot more stitched images and hdr....with whatever camera I have by then....