I'm using a Nikon D300 and shooting raw. The defaults for long exposure NR and high ISO NR were set to OFF by default. Except for shooting delays, is there a quality advantage to doing in camera NR prior to post processing or should these settings be left OFF if planning to do post processing?
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Sorry for my canon-oriented answer - I don't know the D300 but here are my 2c's anyway...
These 2 things may not be the same : if "long exposure NR" means the camera taking a black frame of same duration and substract it if from the picture, it deals with mainly dead and hot pixels, and may be seen as hardware-related NR - something that's hard to do in PP.
Do it if you can afford it time- and battery-wise (and if I'm not mistaken in what it is ;o).
Otoh, I understand "high ISO NR" as a more conventional NR, more or less averaging adjacent values.
This may be better made in a powerful computer than in your camera.