I have never shot macro in my life - it's not how I see though I admire much of the work others produce.
I do have a reasonable technical grounding in photography however and can promise you that you need to stop down! People with a stronger background than me in LF and macro work will be able to explain to you in more detail the problems that you will come up against with depth of field and focussing but suffice to say, depending on your subject matter and the enlargements you are expecting to make, it's going to be a hurdle.
Good luck with your project, I look forward to seeing the results.
PS - I don't go there often a the moment as I'm shooting available light right now - but Strobist has several macro types doing some cool stuff with light using car boot sale equipment, lenses from 1940something and araldite - well worth a look.