Capture Sharpening, if done correctly, is very gentle and a precursor for creative and output sharpening, if you sharpen using the PK logic or PKS itself. I do capture sharpening just after rendering the image from the raw converter. The real inter-play you need to be mindful of is that between local contrast enhancement (LCE) and output sharpening. The combination of the two, if either is overdone, can result in excessively "crinkly" images. But in general, one should use LCE for its intended purpose and if necessary fine tune Output Sharpening in light of the LCE usage. I do LCE using an Action I wrote of John Paul Caponigro's mid-tone high pass contrast enhancement technique (his technical paper is available free on his website once you sign-up). It sits on its own stamp-image layer, and I use PKS for Output Sharpening. This way I can control the strength of each by adjusting opacity, or by using layer masks for working on specific areas of the image.
Mark