SpyderX (and also Spyder5) will work properly on M1 systems under Intel emulation, using the latest Big Sur-compatible releases of Spyder software from November 2020.
SpyderCheckr and SpyderPRINT, the latest releases from November 2020, likewise work properly on M1 systems under Intel emulation.
Performance is excellent - a couple of extra bounces on the first launch, and instant launches after that. Calibration works as usual and it's a snap. User interfaces run fast and seamless. Intel "emulation" is actually Rosetta2 translating the entirety of the applications and their components, internal plugin code, etc. from Intel to Apple Silicon/ARM and it's the fully translated executables that run after that. (This is why for the vast majority of typical consumer applications, running Intel versions for now, before they're eventually rebuilt to include Apple Silicon code in a Universal build, will run just as quickly, and sometimes even more quickly, than they do on older, and often more expensive Intel Apple Macs.)
There's a small bug in Big Sur itself on M1 hardware only (it's fine on Big Sur/Intel) in which Big Sur isn't returning default names for the attached displays. Spyder display calibration software works around this by defaulting to a hard-coded "UNKNOWN-X". This can simply be over-typed by the user and named anything they want ("Macbook Pro LCD", "Color LCD", etc) and then that name is remembered by the software after that. But this doesn't get in the way of calibration or anything else that happens afterward.
The biggest potential issue with these initial M1 systems in general is lack of support for more than 2 displays per system. For laptops: it's just the built in display and one external; clamshell mode doesn't allow it to run 2 externals, as can be done with an M1 Mac Mini. The "workaround" that's been going around is to use DisplayMate adapters to generate additional software-based extensions to external displays over USB. (I'd used an older DisplayMate to do this years ago). However, I don't recall of these can be color managed and calibrated; if not, they'd be accessory displays only, but not something to use for actual photo editing. Apple's SideCar feature can also be used to run an iPad as an extra display (but again - likely not color managed).
David Miller
Manager/Lead Developer, Consumer Graphics Software
Datacolor