I've been using Topaz Gigapixel for a couple of years now, and have found it quite useful on occasion (albeit less so since Adobe introduced its "super resolution" option), but it has some quirks I find disconcerting.
First, if you have Gigapixel emit a DNG, what you appear to get is not a traditional Linear DNG but the equivalent of a fully-baked TIFF in a DNG container. Below: the respective file sizes of an RGB raw file (Fuji X-Trans), the 2X enlargement produced by Gigapixel from that raw file, and the 2X enlargement produced by Lightroom from the same raw file:
-rw-r--r-- 1 ck staff 12M Nov 9 18:35 _XT47993.RAF
-rw-r--r-- 1 ck staff 596M Dec 31 16:17 _XT47993-standard-scale-2_00x-gigapixel.dng
-rw-r--r-- 1 ck staff 163M Dec 31 16:21 _XT47993-Enhanced.dng
Although the Adobe super resolution file has been demosaiced (i.e., it's a Linear DNG), it can in some important respects be treated as a raw file—specifically for adjusting white balance and making other color corrections. As far as I can tell—I'm no expert on this stuff, and am prepared to be proved wrong—the Gigapixel DNG is really just a fully-baked TIFF in DNG's clothing.
More irritating from my perspective is that Gigapixel appears to try to "normalize" the tone curve of any raw image it enlarges by stretching out the tonal values so they cover the full range between black and white. That may be what the user wants, but I have not found any way to defeat this behavior and I would rather be able to control the image tones myself: when I use Gigapixel, I just want it to rebuild the image with larger linear pixel dimensions and not perform any default "editing" for me.