Thank you, Jim. I had left out of the OP the backstory of why I'm working with 8-bit PSDs (instead of "15+"), but had written it up for another purpose. This is it (everything began with NEFs or DNGs and "all their bits"):
For a custom printing job of black and white photographs, I’ve been asked to submit to the printer flattened 8-bit grayscale PSDs at 300 ppi; they will be printed at 6.3x4.2 inches. Most of the images have no or little sky, or areas of flat tone, or areas with smooth gradients without any details.
Some of the images required going through as many as four proofs, and for each file that needed to be reworked (that is, for the 2nd, 3rd, and 4th proofs, as may have been necessary), I copied the previous 8-bit grayscale file and added to the copy the adjustments I thought would work. (I am aware that I could have gone back to the original PSD and reworked it rather than work on a copy of the previous small 8-bit grayscale file, but it was more convenient to do it the way I did).
For all the 8-bit files I sent for the first proof, the histogram was smooth; the data loss began to appear in those files that needed subsequent alterations.