While the two profiles have a similar gamut, the characterization of the red response is rather different.
Plucking a value from the cheek of the image you showed earlier of RGB 210 134 111, and assuming the image is encoded in sRGB space, I get an L*a*b* value of roughly 65 31 27. Running that through the earlier profile I get an RGB of about 212 88 88. With the new profile I get 102 102 88 - substantially different. The A2B and B2A tables are consistent in this, so there's nothing wrong with the table construction, implying it is in the original patch data.
Unfortunately I can't find any usable patch data in the ICC profiles (The CxF tag appears to be in some binary format rather than canonical XML).
Graeme, I extracted the CGATs (See attached) and also noticed the white points were quite different.
I get some rather curious results looking at the CGATS data embedded in the profiles. They are from different spectros:
CGATS: CSI 4900 2880 RGB Espon UPP Matte_M2.txt
ORIGINATOR "i1Profiler - X-Rite, Inc."
INSTRUMENTATION "i1iSis 2 ; Serial number 11929"
DESCRIPTOR "CSI 4900 2880 RGB Espon UPP Matte_M2"
MEASUREMENT_SOURCE "MeasurementCondition=M2 Filter=UVcut"
CGATS: CSI 4900 1440 RGB Epson UltraPremPres Matte_M2.txt
ORIGINATOR "i1Profiler - X-Rite, Inc."
INSTRUMENTATION "i1iSis ; Serial number 5652"
DESCRIPTOR "CSI 4900 1440 RGB Epson UltraPremPres Matte"
MEASUREMENT_SOURCE "MeasurementCondition=M2 Filter=UVcut"
Secondly, the white points are quite different. Since whites are unprinted paper they should be reasonably close to each other. At least < 2 dE. These are over 3 dE1976 different.
Perhaps the ISIS 2 and ISIS differ that much but it seems a bit larger than usual. Perhaps the calibration tiles are dirty or aged. a b* of 4.4 seems pretty yellowish
First WP, Lab 94.98 -0.60 4.41
Second WP, Lab 96.03 -0.83 1.48
sRGB(210, 134, 111) -> Lab (63.7, 28.1, 25.2)
Running that lab through AtoB1 in Abs yields:
CSI 4900 1440 RGB Epson UltraPremPres Matte.icc -> Lab (63.6, 28.0, 25.1)
CSI 4900 2880 RGB Espon UPP Matte_M2.icc -> Lab (65.9, 45.8, 27.1)
Which are hugely off. I note that the print resolution differs, 1440 v 2880, perhaps that is the cause but generally driver settings for dpi don't have that much shift in my experience. Maybe 2 or 3 dE is typical. This is close to 20.
Attached are the extracted CGATS for M2 measurements.