I upgraded to Mojave on my MacBook to make sure most of what I need & use worked fine and including MS Office 2011, everything works fine. You get a "warning" that some apps won't work in the next OS update and to check with the developer but I think most of it is just to get you on the upgrade train...
For my main system, I took a spare drive and cloned my system before I updated to Mojave to see what issues I may encounter since I keep different apps on it. Since I've still on several projects, I haven't had a chance to try everything, but most of my software seemed compatible. When my plate is cleared from these projects in a month or so, I'll be able to take the time to test Mojave more on my ancient MacPro 5.1 that's been upgraded extensively in the ten years I've used it, but at least in my limited testing, it seems to work fine with nearly all of my key applications so far.
If you have a spare drive (they are dirt cheap!), clone your system, upgrade it to Mojave, then give it a try to see what works for you.