This issue was dealt with in this blog on the 3800.
http://www.outbackphoto.com/printinginsights/pi045/essay.html#20070206
Reassuring reading. However it doesn't tally with my experience. I've recently been running tests with my Epson 3880, comparing the rendering of fine detail with the settings '1440/high speed on' vs '2880/high speed off/fine detail on'. Even with a loupe, it is hard to see any difference in the presentation of fine detail (though if pressed, I'd say that the latter settings give a sightly superior result). However only a casual glance at the two prints is necessary to reveal a difference in colour. One print is warmer and more saturated than the other. So on my setup it seems that separate custom profiles will be necessary if I'm going to switch between different print driver settings (1440/2880, High Speed On/Off, Finest Detail On/Off). — I'm surprised by this, and I'm still exploring...
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Further exploring...
I've now done some more careful tests, running nozzle checks after each print to make sure nothing is amiss. The source image is a sharp Nikon D800 file, downsized to 5"x7.5" at 720ppi. The prints were examined with a loupe, and also scanned on a flatbed for closer examination. In total, four prints were made, with the following driver settings:
1. 1440 High Speed
2. 1440
3. 2800
4. 2880 Finest Detail
Observations:
1. There is no difference between prints 1 and 2. Using 'High Speed' has no negative effect on print quality.
2. From a distance, prints 3 and 4 look the same as each other, and they look different from prints 1 and 2. The difference is that they have slightly less density in the midtones. In Photoshop terms, they can be corrected to match prints 1 and 2 by adjusting the middle Levels slider from 1.00 to 0.96. Therefore on my printer I would say that switching from 1440 to 2880 has a subtle but significant effect on the tonality of the image, and to compensate for this separate profiles should be made.
3. Viewed close-up, with a loupe and (especially) with a high res flatbed scan, there is a significant difference in the rendering of fine detail between prints 3 and 4. Checking 'Finest Detail', contrary to the Epson manual, renders photographic detail more finely.