Alan, I know you know ;-)
Sometimes people need to listen to those of us that actually own this kit and trust us to be helpful, even if it's not what they want to hear.
Yes, I did actually listen.
I listened to Andrew Rodney who mentioned the inbuilt dongle in the Spectrolino and GWGill who said ArgyllCMS will directly drive the instrument. Also listened to DP running two units with Keyspan adapter and also GWGill warning about losing firmware.
I also listened to Alexey.Danilchenko using ArgyllCMS to drive the exact spectroscan that I am looking at. Interface device not mentioned.
So the upshot of this appears to be that the Spectroscan can be run successfully from a modern OS using the well respected ArgyllCMS
The problem with the Prolific adapter is the fact that the chip has been discontinued and understandably no driver support. From that supplier however there are a number of PL 2303 that are Windows 10 and MacOS compliant. So what I was looking for was any comment about specific adapters apart from the Keyspan.
Once again I will stress that I do not own this unit I have merely been given it to play with for a day or two. I have no intention now of running a separate PC or Mac just for this one job.
Sometimes people who own pieces of kit also need to listen to other users different helpful replies rather than try making smart ass replies