Hi Dave,
If you refer to this image:

, how could I tell? The image is just web size. Still, it may have an oversharpened look.
To a significant effect, loss of sharpness can be compensated by sharpening. So, you can lose acutance and it can be restored using deconvolution sharpening. But, starting with a sharp image would be preferable.
Also, stopping down more than needed mean that you may need to use a higher ISO which will increase noise and reduce dynamic range.
It may seem to make little sense to buy an expensive lens, that performs best at f/4 and use it at small apertures.
On the other hand, it is possible to recover detail until a certain limit with appropriate sharpening.
Here are two real world examples (shot on Sony A7rII with a Sigma 24-105/4 Art), both are 1:1 crops.

In my view the f/8 image is visibly sharper than the f/11 image. That could be compensated by sharpening, of course.

Here I wanted to have long exposure for the water, so I used f/22, but I also wanted a sharp building so I shot another image at f/8. The left image is f/22 the center f/8, the image on the right was f/22 but sharpened by ImageMagic that does deconvolution.
Note that center image has moiré, indicating lens outresolves sensor. That is not visible in f/22 images.
Resolution does not matter for web size images. But my intention is that the images I make will be usable at 40"x60" print size.
Best regards
Erik
Well I can only tell you what my eyes are seeing, as I have no other way to measure this, nor would I want to waste any time trying to do so.
Just look at the shot I posted several pages ago on this thread, is it sharp enough? Yes I think so. Are there any diffraction or CA issues within it? Well not that I can see. So yes you may be able to show me graphs and scientific papers that tell me the physics are saying one thing, but all I can say is that my eyes are telling me that with this sensor and these old lenses, that CA and diffraction etc, are no longer an issue worth worrying about.
But of course Erik, if you wish to worry about these issues, then that is fair enough and I would not wish to argue with you or anyone else on this, but for me, it simply comes down to the technology having now evolved to the point, where it has become good enough for such technical considerations as these, to have become a thing of the past.
all the best everyone

Dave