I am mostly interested in sharpening landscape images for output to a printer, shot with my Canon 5Dsr; prints are often 24 in x 36 in, or larger. I am also finding Sharpen AI processing times are relatively slow on my 8 month old Maingear Vybe computer (i7-7820x, Turbo, 32 GB RAM, SSD drives, nvidia-Quadro P2000 5B)... typically about 2 min. However, this is relatively short compared to the 20 or 30 minutes it might take for a print to complete! With limited image inspecting on my monitor only (so far) I can clearly see differences between the following sharpening programs: Photokit Output Sharpener 2/Glossy, Topaz Detail 3 (Overall Detail Light 2), Topaz InFocus (e.g. Est Blur (0.75,0.65, 1.15), and Topaz Sharpen AI (0.8, 0, 0).
For monitor views at 50% and esp 100% the Sharpen AI results are most pleasing to me... for lack of a better description, they seem more refined and natural, more detailed without the artificial microcontrast build up produced by Photokit Sharpener and Topaz Detail 3. Topaz InFocus, with appropriate settings, comes closer to Sharpen AI in what I've seen so far. The real test for me is what it does for color and B/W prints. I don't have result for that yet. I don't expect any of these sharpening methods to have any effect on my website images (I always shoot on a tripod so the "Stabilize" mode of Sharpen AI probably won't be needed). I should also mention that I do find Topaz Detail useful for website images on occasion vs. it's possible use for prints. Also, I have see some possibilities for Sharpen AI with my Pentax 67 film shots, although I doubt Topaz trained the algorithm on film images.