No necessarily so. The pixels are subsampled for the zooming out of the image, that can absolutely affect color and tone. Hence, it is always recommended for precise inspection of images to view at 100% (1:1). Ditto for Lightroom but in Develop not the other modules.
The problem is that you want to see the whole picture as you would do with a print or on a screen. In the end the tonal relationships are more important than the details
Most screens aren't big enough to display 5000x 3000 or bigger 1:1.
So you have to do most of the work in a smaller scale and when you're finished and satisfied, then flatten.
And then "it" happens
It seems to me that flattening with the 100% view solves the problem, no changes that I noticed, even scaling back to 33% e.g.
If you flatten instead at 33% then I'm not sure of what I'm getting
Please correct me if I'm wrong